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Titlebook: Bone Morphogenetic Proteins: From Local to Systemic Therapeutics; Slobodan Vukicevic,Kuber T. Sampath Book 2008 Birkhäuser Basel 2008 Tiss

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期刊全称Bone Morphogenetic Proteins: From Local to Systemic Therapeutics
影响因子2023Slobodan Vukicevic,Kuber T. Sampath
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发行地址Completes the series of PIR-volumes on BMPs by S. Vukicevic/K.T. Sampath with most recent data (Bone Morphogenetic Proteins - Regeneration of Bone and Beyond / 2004; and Bone Morphogenetic Proteins -
学科分类Progress in Inflammation Research
图书封面Titlebook: Bone Morphogenetic Proteins: From Local to Systemic Therapeutics;  Slobodan Vukicevic,Kuber T. Sampath Book 2008 Birkhäuser Basel 2008 Tiss
影响因子.Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), originally identified from bone have been successfully used to regenerate the bone in humans. Most recent preclinical data suggests that BMPs have a potential to provide protection against inflammation and fibrosis in acute and chronic injury of parenchymal tissues when applied systemically to sustain the function of kidney and liver. The application of BMPs from a local to systemic utility is a rapidly growing field, gaining interest among researchers and biotech entrepreneurs. ...In this volume, we summarize the advances made on the local and systemic use of BMPs including chapters covering the regulation of BMP-signalling pathways, biological actions of BMPs in bone, cartilage and teeth, as well as clinical applications and potential system
Pindex Book 2008
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Basic Principles of Specimen Collectioned as the TGF-β superfamily with a large subgroup of proteins named BMPs and growth and differentiation factors (GDFs). With a few exceptions, BMPs and GDFs are capable of inducing ectopic bone and or cartilage formation . and ..
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Use of recombinant human BMP-2 in orthopedic trauma,. This recombinant production process is similar to the method used to manufacture human insulin and other protein-based drugs (such as erythropoietin and interferon); it enables the reproducible production of a single BMP, at a known concentration and at very high purity. The availability of recomb
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