Titlebook: Bone Metastasis and Molecular Mechanisms; Pathophysiology Gurmit Singh (Director of Research, Professor of P Book 2004 Springer Science+Bus

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Models of Breast Cancer Metastasis to Bone: Characterization of a Clinically Relevant Model,te of metastasis of some other cancers, including prostate. Bone metastases in breast cancer are predominantly osteolytic due to the resorption of bone following excessive activation of osteoclasts. This leads to major clinical problems including severe pain, hypercalcemia, bone fractures and nerve-

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Comparative Morphometric Study on Bone Remodeling in Human Specimens and in Experimental Models of pathological fracture, spinal compression syndromes and hypercalcemia. Bone destruction is a marked clinical feature and the major source of morbidity associated with bone metastases. Most of these clinical features can be related to structural changes in bone that are caused by effects of the tumor

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Metastasis in the Bone Marrow Microenvironment,astasis to the bone marrow. The extensive changes induced by cancer metastasis in bone (either lytic, or more rarely, sclerotic) represent secondary changes induced to fulfill the need of cancer cells for their anti-homeostatic growth. A common biological paradigm — “the seed and the soil” — is used

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The Role of Tumor-Associated Macrophages in Metastasis-Associated Osteolysis,umors not only have the potential for metastasis at a relatively early stage of the disease but can also produce metastases many years after adequate local treatment (1, 2). A significant macrophage infiltrate is often found in these metastatic cancers. On the basis that monocytes and macrophages ar

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The Malignant Hierarchy in Multiple Myeloma: Relationships between Malignant Cells and Bone Disease from hematological malignancies. It is characterized by monoclonal immunoglobulin (mIg) in the blood, lytic bone lesions, and monoclonal plasma cells in the BM. These plasma cells are responsible for most symptoms of MM, but considerable work confirms that the MM clone also includes earlier stage B

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Angiogenesis and Lymphangiogenesis in Metastatic Bone Disease: A Matter of Networking, cycle). In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. In pathologic conditions, however, this delicate balance can be disrupted and lead to initiation and stimulation of blood or lymphatic vessel formati

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Prostate Cancer: Models for Developing Novel Therapeutic Approaches,men and is the second leading cause of cancer mortality following lung cancer (1–3). Recently, increases in the number of men diagnosed with prostate cancer has been attributed to an increase in the awareness of the disease as well as to better improvements in screening and detection. However, despi

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Potential Therapeutic Targets for Bone Metastasis,o spread to bone amongst which are the three most common cancers — lung, breast and prostate. Patients with lung cancer are more likely to succumb quickly to their disease than those with breast or prostate tumors in whom, relatively, bone metastases are more of a problem. Patients with advanced bre