Titlebook: Bone Marrow Transplantation; Richard Champlin Book 1990 Kluwer Academic Publishers 1990 anemia.bone marrow.diseases.immunodeficiency.infec

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Bone marrow transplantation: Introduction and overview1–5]. Three sources of hematopoietic cells can be used: . bone marrow from a related or unrelated donor, . marrow from a genetically identical twin, or . bone marrow or peripheral blood stem cells. Over 4000 patients per year receive allogeneic bone marrow transplants at more than 250 centers worldw

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Chronic graft-versus-host diseasetransplant centers has expanded to more than 200 institutions [1,2]. Utilization will continue to increase as the number of available marrow donors increases through selection of suitable HLA-nonidentical family or unrelated marrow donors [3–5].

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T-cell depletion for bone marrow transplantation: Effects on graft rejection, graft-versus-host disenosuppressive therapy with cyclosporine or methotrexate, moderate to severe acute GVHD develops in approximately 45% of transplant recipients with an HLA-identical sibling donor [4] and in >75% of patients from HLA-nonidentical relatives [5]. Recently, bone marrow transplants have been performed fro

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