Titlebook: Bone Adaptation; In Silico Approach Yoshitaka Kameo,Ken-ichi Tsubota,Taiji Adachi Book 2018 Springer Japan KK 2018 Bone Remodeling.Cellular

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Microscopic Fluid Flow Analysis in an Osteocyte Canaliculus,lular mechanotransduction. A three-dimensional simulation model of an osteocyte process within a canaliculus was reconstructed based on serial tomographic images obtained by ultra-high voltage electron microscopy. The fluid flow simulation predicts the generation of highly inhomogeneous flow pattern

Condescending

Macroscopic Fluid Flow Analysis in a Poroelastic Trabecula,ate the response of the interstitial fluid pressure within a single trabecula to the applied cyclic loading. By assuming a single trabecula as a two-dimensional poroelastic material, we present an analytical solution for the interstitial fluid pressure in a single trabecula as a summation of the tra

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Modeling Trabecular Bone Adaptation Induced by Flow Stimuli to Osteocytes,nd intercellular communication. This model postulates that osteocytes, as mechanosensory cells, are stimulated by interstitial fluid flow to regulate bone adaptation. The morphological changes in trabeculae, in response to the mechanical environment, are demonstrated with the help of a voxel finite

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Trabecular Surface Remodeling Toward Uniform Local Stress State,ar structure due to bone remodeling toward uniform local stress state. Nonuniformity in the local stress distribution on the trabecular surface is assumed to be the driving force of the remodeling. The trabecular structure is computationally modeled with an assemblage of pixel finite elements, and t

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Spatial and Temporal Regulation of Cancellous Bone Structure by Trabecular Surface Remodeling,nd temporal changes in the trabecular structure caused by remodeling. Two model parameters, the threshold value of the lazy zone and the sensing distance of the mechanical environment, are introduced into the remodeling rate equation to express the sensitivity of bone cells to mechanical stimuli. A

FEIGN

Comparison of Mechanical Quantities as Bone Remodeling Stimuli,ibution functions of the mechanical quantities were evaluated by using digital image-based finite element models of rat vertebral bodies subject to physiological loading conditions. Strain energy density (SED) and von Mises equivalent stress were considered as local mechanical quantities, while SED

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