Titlebook: Blue Biotechnology; From Gene to Bioacti Werner E. G. Müller,Heinz C.‘Schröder,Xiaohong Wan Book 2017 Springer International Publishing AG

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Entotheonella Bacteria as Source of Sponge-Derived Natural Products: Opportunities for Biotechnologinable production systems. This chapter covers research efforts that have taken place over the past few years involving the identification of ‘Entotheonella‘ symbionts responsible for production of sponge compounds, as well as the elucidation of their biosynthetic routes, highlighting future biotechnological applications.

Urgency

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Discovery and Development of Novel Drugs, by Preclinical, Clinical and Non-Clinical Development. Discovery phase is divided in Hit Finding, Lead generation, Lead Optimisation and Candidate Identification Phase. Main drivers of the whole process are regulatory requirements and the aim to eliminate the unnecessary spending by early eliminati

Moderate

Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structhas been employed to gain insight into the mechanism of action of new antimalarial agents characterized by the scaffold of the marine compounds plakortin and aplidinone. The results of this approach show that these molecules, after interaction with Fe(II), likely coming from the heme molecule, give

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Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversificatiived from natural products. The generation of analogues of these bioactive natural products is important in order to gain a greater understanding of structure activity relationships; probing the mechanism of action, as well as to optimise the natural product’s bioactivity and bioavailability. This c

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New Target Sites for Treatment of Osteoporosis,ain challenging diseases with a large burden for the public health systems. Among these new agents promoting bone formation, shifting the impaired equilibrium between bone anabolism and bone catabolism in the direction of bone synthesis are inorganic polymers, in particular inorganic polyphosphates

Talkative

Biocalcite and Carbonic Acid Activators,ormation of the inorganic skeletons from the simplest animals, the sponges, up to humans. Focusing on skeletons based on calcium minerals, the principle enzymes involved are the carbonic anhydrase (formation of the calcium carbonate-based skeletons of many invertebrates like the calcareous sponges,

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毕业典礼

Entotheonella Bacteria as Source of Sponge-Derived Natural Products: Opportunities for Biotechnologmportant source of a wide variety of structurally diverse bioactive natural products. Over the past few decades, a multitude of compounds from sponges have been discovered exhibiting diverse, pharmacologically promising activities. However, in many cases the low substance quantities present in the s

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Book 2001t molecular species. Analysis of the amplitude of concentration fluctuations can provide a wealth of information about aggregation/polymerization process and the compositions of mixtures. Furthermore, FCS provides a bridge between conventional measurements of dynamic processes on a macroscopic conce