Titlebook: Blood Cell Biochemistry; Hematopoiesis and Ge Leslie J. Fairbairn,Nydia G. Testa Book 1999 Kluwer Academic / Plenum Publishers 1999 HIV.bio

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https://doi.org/10.1007/978-3-531-91123-6h groups to investigate antisense as an experimental and therapeutic tool. In the early 1980s little further work was conducted mainly because of the difficulties in reliably synthesizing adequate quantities of DNA oligonucleotides. However, innovative biotechnology companies developed DNA synthesis

diathermy

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Genetic Approaches to Therapy for the Hemoglobinopathies,lypeptide ratio (thalassaemia) of hemoglobin (Hb) or abnormalities in the function of the β-globin chain (sickle cell disease) (see .; .). It is estimated that approximately 250 million people carry hemoglobinopathies worldwide. This gives rise to more than 300,000 births each year that are homozygous for either thalassaemia or sickle cell disease.

single

Hemopoietic Stem Cells as Targets for Genetic Manipulation, an irradiated mouse (.). Again, the proportion of mice reconstituted after injection with a single cell agrees with the expected proportion of cells that seed in the bone marrow. Transplantation studies with marked murine cells have demonstrated that monoclonal or oligoclonal hematopoiesis occurs f