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Titlebook: Bioresponse-Linked Instrumental Analysis; Bertold Hock Textbook 20011st edition B. G. Teubner GmbH, Stuttgart/Leipzig/Wiesbaden 2001 Analy

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期刊全称Bioresponse-Linked Instrumental Analysis
影响因子2023Bertold Hock
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发行地址Die wirkungsbezogene Analytik kombiniert biomolekulare Erkennungsprozesse, die im Organismus einen biologischen Effekt auslösen, mit der chemischen Analytik.
学科分类Teubner-Reihe Umwelt
图书封面Titlebook: Bioresponse-Linked Instrumental Analysis;  Bertold Hock Textbook 20011st edition B. G. Teubner GmbH, Stuttgart/Leipzig/Wiesbaden 2001 Analy
影响因子Bioresponse-linked instrumental analysis combines biomolecular recognition, initiating a biological effect in the organism, and chemical analysis. Although this technology is only at its beginning, the power of this approach is obvious. It provides both, information on effects with respect to the applied target structures as well as the chemical structure and concentration of active substances present in a sample. In this book, examples ranging from endocrine disruptors to neurotoxic substances are used to illustrate the principle.
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Detection of Bioeffective Environmental Compounds by High-Performance Thin Layer Chromatography,od. In the case of High Performance Thin Layer Chromatography (HPTLC) the separated components can be detected and quantified directly on the chromatogram by physical and chemical methods. Coupling high performance thin-layer chromatography with biological or biochemical inhibition tests it is possi
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Bioresponse-Linked Analysis Based on Acetylcholinesterase Inhibition,and other neurotoxins such as algal toxins. Its high sensitivity, rapid turn-over, and stability promoted its use in analytical applications to detect pesticides at low concentrations in environmental samples. It is possible today to produce this enzyme recombinantly in different systems and to engi
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Transport Proteins in Blood: A Possible Role in Hormone Disrupting Effects of Pollutants, for the assessment of such activities. Contaminants may affect hormonal systems at several levels. With regard to steroid and thyroid hormones it is known that there exists a delicate balance between the free and bound fraction in mammal blood, which defines the hormonal status of an organism. For
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,Proteomics — A Tool for Bioresponse-Linked Analysis,centrations (up- or down-regulation of protein expression), enzyme activity or covalent protein modifications, such as phosphorylation or glycosylation. Driven by pharmaceutical research methods of protein analysis improved significantly leading to 2-D protein patterns with several hundred proteins
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Conclusions and Outlook,affinity usually suffer from cross-rectivities. Thus species-specific analysis based on biomolecular recognition is in most cases not possible. Bioresponse-linked instrumental analysis combines biomolecular recognition, initiating a biological effect in the organism, and chemical analysis. Although
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Textbook 20011st editionhough this technology is only at its beginning, the power of this approach is obvious. It provides both, information on effects with respect to the applied target structures as well as the chemical structure and concentration of active substances present in a sample. In this book, examples ranging f
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