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Titlebook: Biopsy pathology of muscle; Michael Swash,Martin S. Schwartz Book 1984 Springer Science+Business Media New York 1984 biopsy.electron micro

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期刊全称Biopsy pathology of muscle
影响因子2023Michael Swash,Martin S. Schwartz
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学科分类Biopsy Pathology Series
图书封面Titlebook: Biopsy pathology of muscle;  Michael Swash,Martin S. Schwartz Book 1984 Springer Science+Business Media New York 1984 biopsy.electron micro
影响因子During the last 20 years the development of enzyme histochemical techniques has contributed greatly to knowledge of muscle pathology. However, these and other new methods, such as electron microscopy and immunocytochemistry, have only relatively recently become gener­ ally available for routine use in histopathology. Muscle biopsy is a long-established technique in clinical practice, having been introduced by Duchenne in 1868 (Arch. Gen. Med. , 11, 5-179). However, the needle method used by Duchenne was not generally adopted, although Shank and Hoagland described a similar technique in 1943 (Science, 98, 592). During this time muscle biopsies required a surgical procedure and this was a considerable disincentive to their use. It was not until Bergstrom (1962; Scand. J. Clin. Lab. Invest. , 14, Suppl. 68) and Edwards (1971; Lancet, ii, 593--6) developed a simple biopsy needle suitable for muscle work in connection with exercise physiology that the advantages of needle muscle biopsies came to be appreciated. Since then, muscle biopsies have become a relatively minor procedure. This has led to the increasing use of muscle biopsy in clinical practice, both for diagnosis and for assessi
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Laboratory methods,hin the needle and is not therefore likely to be handled before it is given to the technician. Another source of artefact is the injection of local anaesthetic deeply into the muscle at the biopsy site. This results in disruption of the muscle tissue. Local anaesthetic should therefore only be injec
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itable for muscle work in connection with exercise physiology that the advantages of needle muscle biopsies came to be appreciated. Since then, muscle biopsies have become a relatively minor procedure. This has led to the increasing use of muscle biopsy in clinical practice, both for diagnosis and for assessi978-0-412-24420-9978-1-4899-3402-4
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Laboratory methods,Fig. 2.1) can be performed at any convenient location (Edwards, 1971). In order to obtain a specimen free of artefact and thus suitable both for light and electron microscopy it is important to maintain a scrupulous technique in handling the biopsy. In the case of open muscle biopsy the surgeon and
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Histological features of myopathic and neurogenic disorders,ight increase in central nucleation, which may only be recognized by morphometric and statistical analysis, are not generally important in diagnosis, unless they are accompanied by other, more obvious changes. However, in some conditions, such as McArdle’s disease, the routine histological and enzym
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