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Titlebook: Biopharmaceutical Drug Design and Development; Susanna Wu-Pong (Director),Yon Rojanasakul (Profes Book 2008Latest edition Humana Press 200

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The Human Genome Project and Drug Development,r goals included sequencing other genomes, developing new related technology, making the technology widely accessible, and examining the ethical, legal, and social implications of the project. The implications of the HGP on the current methods used in biomedical research and its impact on future hea
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The Use of Bioinformatics and Chemogenomics in Drug Discovery,tabases are offering new avenues for the identification of novel genes and drug targets. This communication reviews how bioinformatics and chemogenomics are used for new gene identification, selection of genes or proteins that may be potential drug targets, and the screening of libraries, both in vi
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Microarray Technology Using Proteins, Cells, and Tissues,analysis. This chapter reviews the current status of protein microarray assays and highlights efforts using cells and tissues on microarrays. These ‘other’ microarrays have the potential to yield highly parallel miniaturized assays that will accelerate drug discovery efforts and facilitate understan
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Pharmacogenetic Issues in Biopharmaceutical Drug Development,ted biotherapeutic molecules, make this an exciting era in personalized medicine. Pharmacogenetics, the term used to describe idiosyncratic responses to drug therapy having a genetic basis, has become much more than a few SNPs in some drug-metabolizing enzymes. With the advent of biopharmaceutical d
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Stem Cell Technology and Drug Development,apies or by identification of drugs using high-throughput stem cell cultures differentiated into specific mature cell types. This promising technology is based on isolation of pluripotent cells that can be expanded in culture and differentiated into a mature phenotype. In addition to the social and
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Small Nucleic Acid-Based Drugs: Successes and Pitfalls,ve used this technique for functional genomics or to test these molecules as potential therapeutic agents. During this time, the field has evolved from simple phosphodiester oligonucleotide (ODN) binding to complementary mRNA in vitro, to the development of hundreds of chemically modified ODNs with
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