| 期刊全称 | Biomedical Applications of Acridines | | 期刊简称 | Derivatives, Synthes | | 影响因子2023 | Jan Ježek,Jan Hlaváček,Jaroslav Šebestík | | 视频video | | | 发行地址 | Describes modern and conventional syntheses of acridine scaffolds.Presents structural aspects of interactions with proteins which provide useful tips for designing enzyme inhibitors involved in the tr | | 学科分类 | Progress in Drug Research | | 图书封面 |  | | 影响因子 | .This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy. . | | Pindex | Book 2017 |
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发表于 2025-3-21 18:15:12
