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Titlebook: Biomarkers in Inflammatory Bowel Diseases; Nik Sheng Ding,Peter De Cruz Textbook 2019 Springer Nature Switzerland AG 2019 Inflammatory Bow

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Clinical Risk Factors: Lessons from Epidemiologychemical, and endoscopic remission, with ultimate outcomes involving prevention of disease progression, surgery, or hospitalization. Thus, risk assessment and prediction of expected disease course by clinical, biochemical, and endoscopic markers has become important in patient stratification, manage
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Luminal Crohn’s Diseaseefore, obtaining an accurate assessment of disease activity is paramount for risk-stratifying patients and initiating or escalating therapy when appropriate. Within the classic management paradigm, treatment decisions have been largely predicated on patient-reported symptoms. However, more recent ev
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Fibrosis and Stricturing Disease in Crohn’s Diseasefibrostenosing CD and the need for surgery have largely remained unchanged despite the use of anti-inflammatory drugs including biologics. Fibrosis is a common occurrence in ulcerative colitis. Clinical, serologic, and imaging markers lack accuracy to predict, diagnose, and prognosticate fibrostenos
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Postoperative Crohn’s Disease. It will discuss the optimal management of Crohn’s disease following resectional surgery with reference to the natural history of Crohn’s disease after surgery, risk factors for earlier postoperative recurrence, diagnosis and monitoring of recurrence and therapeutic strategies to address prevention
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Perianal Crohn’s Diseasesurgical interventions. Perianal Crohn’s disease involves a spectrum of disorders, from fistulising to non-fistulising disease. The aetiology of perianal Crohn’s disease is not well understood. Several biomarkers including the presence of anti-. antibodies (ASCA) and OmpC antibody and persistently h
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Biomarkers in Acute Severe Ulcerative Colitis/failure and salvage therapy response/failure. It will provide a clinical algorithm encompassing biomarkers to help guide clinical management as well as identify future directions for ongoing research.
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Chronic Active Ulcerative Colitisortant role in understanding the individual disease phenotype. Disease activity should be proactively monitored with the non-invasive biomarkers CRP and faecal calprotectin, in addition to endoscopic assessment to establish mucosal and histological severity. Serial faecal calprotectins are particula
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