Titlebook: Biomarkers for Immunotherapy of Cancer; Methods and Protocol Magdalena Thurin,Alessandra Cesano,Francesco M. Ma Book 2020 Springer Science+

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978-1-4939-9775-6Springer Science+Business Media, LLC, part of Springer Nature 2020

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Biomarkers for Immunotherapy of Cancer978-1-4939-9773-2Series ISSN 1064-3745 Series E-ISSN 1940-6029

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Status of Immune Oncology: Challenges and Opportunitiesely)..This introductory chapter to this book focuses on scientific and technical aspects relevant to the identification and validation of predictive biomarkers for immunotherapy. We emphasize that methods should address both the biology of the tumor and the tumor microenvironment. Moreover, the iden

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Detection of Microsatellite Instability Biomarkers via Next-Generation Sequencing preparation and quality control (QC), and outline the bioinformatics steps necessary for sequence alignment, preprocessing, and MSI-H+ detection using the software tool MANTIS. This workflow is intended to facilitate more widespread usage and adaptation of NGS-powered MSI detection, which can be ev

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Validation of Circulating Tumor DNA Assays for Detection of Metastatic Melanoma In metastatic melanoma, however, obtaining a tissue sample for molecular diagnostics is not typically a major obstacle to patient care plans; rather predicting treatment outcomes and monitoring a patient’s disease course during therapy are considered the current priorities for this cancer type. In

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