Titlebook: Biomarkers for Huntington‘s Disease; Improving Clinical O Elizabeth A. Thomas,Georgia M. Parkin Book 2023 The Editor(s) (if applicable) and

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Positron Emission Tomography (PET) Imaging Biomarkers in Huntington’s Diseases in pwHD have been performed, most of which have claimed subclinical biomarker (e.g. phosphodiesterase 10a, dopaminergic receptors) impairment before the appearance of overt HD symptoms. This finding stresses the importance of early detection and potential intervention, decades before age of onset.

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Proteomics in Huntington’s Disease Biomarker Discovery tissues and models, several known and novel candidates emerged as consistently affected in HD. Based on MS-based HD studies, we propose the monitoring of existing markers mutant Huntingtin (mHTT) and neurofilament light polypeptide (NfL), together with novel candidate markers, such as proenkephalin

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Microbiome and Metabolomic Biomarkers for Huntington’s Diseaseate biomarkers, including components of the gut microbiome and circulating metabolites. Changes to gut microbiome composition can be quantified using a variety of sequencing methods. This includes polymerase chain reaction, 16S rRNA sequencing, and metagenomic analysis. Metabolomic techniques can be

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TAR DNA-Binding Protein 43 as a Potential Biomarker for Huntington’s DiseaseHowever, several case reports of individuals with the HTT mutation and ALS-like syndrome suggest potential interactions and involvement of TDP-43 in the pathophysiology and phenotype of some individuals with HD. Investigations into other PolyQ diseases, such as Spinocerebellar Ataxias, have provided

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