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Titlebook: Biologie und Epidemiologie der Hormonersatztherapie - Biology and Epidemiology of Hormone Replacemen; Diskussionen zur Pos M. A. Lewis,M. D

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Pathogenesis of Histological Types of Endometrial Cancerr survival rate of 60%. Only the atypical form of endometrial hyperplasia presents a true cancer risk. Hyperestrogenism leads to hyperplasia and therefore may lead to atypical forms which may cause endometrioid adenocarcinoma..It appears that postmenopausal women with unopposed HRT have two to three
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Pathology of the Colon and Ovaryl colon mucosa contains oestrogen receptors, these are methylated, meaning that they are inactive. Oestrogen stabilizes this methylation; therefore a risk reduction can be assumed. Professor Dietel concluded that on the basis of this evidence, HRT can be given to patients with colon cancer.
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The Progenitor Cell Concept of Proliferative Breast Diseaseer. All benign lesions are progenitor cell lesions. In breast cancer, ductal carcinoma shows specific a immuno-phenotype compared with the usual ductal hyperplasia. Breast cancer is not derived from progenitor cells, but usually evolves from glandular differentiated cells. These are the cells which
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Indication for HRT: Climacteric Complaints and OsteoporosisEven 18 years after menopause, 16% of women exhibit considerable vasomotor and other complaints, so that the duration of HRT use needs to be individually gauged. HRT has been shown to reduce sleep disorders, such as insomnia induced by decreased REM sleep and sleep apnea. There is no specific relati
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HRT and Cardiovascular Disease in Womenstudy, no increased or decreased risk of CVD was found for HRT. An increase in risk was found in the first few months, however, which has also been found in the Nurse’s Health study (Grodstein 2000). It should be noted that the WHI included only asymptomatic women and therefore does not reflect the
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The Million Women Studyre were 9,364 cases of breast cancer and 637 deaths from breast cancer. The risk ratio (RR) for current use of HRT against non-use was 1.66, for past use it was 1.01, and the risk disappeared within one year after cessation. Combined HRT showed a RR estimate of 2. The RR of death of breast cancer is
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Paradigm Shift in Causal Thinking in Epidemiologyy should accept this until the null can be rejected with confidence..Related to the loss of scepticism are the following. Small relative risks are often uninterpretable. If there are fragile data based on small numbers then the data need to be almost free of error or biases. If not, they can change
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