Titlebook: Biology and Pathology of Astrocyte-Neuron Interactions; Sergey Fedoroff,Bernhard H. J. Juurlink,Ronald Dou Book 1993 Springer Science+Busi

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The Perinodal Astrocyte: Functional and Developmental Considerationsnode of Ranvier has been documented in numerous CNS tracts and in many species (Waxman and Black 1984; Hildebrand and Waxman 1984; Raine 1984; Sims et al. 1985; Bodega et al. 1987; Sims et al. 1991). Perinodal astrocytes are associated with myelinated axons in a highly specific manner at the nodes o

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Inter-Cellular Signalling by Nitric Oxideger, cyclic GMP (cGMP) (Drummond, 1983). These are now known to be mediated through the release of the novel messenger molecule, nitric oxide (NO), which functions as a powerful activator of the soluble form of the cGMP synthesising enzyme, guanylate cyclase (Garthwaite, 1991). NO has a number of pr

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Production of Nitrosyl Mediators in Astrocytesrs and have been shown to release a number of vaso- and neuroactive compounds (Murphy, 1993). The close spatial relationships of astrocytes with neurons, and with the microvasculature, implicates them in bidirectional signalling processes.

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The Possible Roles of Astrocytes in Energy Metabolism of the Brainrs the narrow extracellular space between the brain cells, the conclusion appears inescapable that the nutrients of the brain, such as the quantitatively most important substrates for the generation of energy, glucose and oxygen, must cross the astrocytes to reach their metabolic destination in the

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Role of Peroxidase-Positive Astrocytes in Estradiol-Related Hypothalamic Damageasis, sequestration and metabolism of various neurotransmitters, antigen presentation to immunocytes and elaboration of a scaffolding for neuronal migration during embryogenesis (Fedoroff & Vernadakis, 1986A; Wilkin et al., 1990). On the other hand, astrocytes may, under certain circumstances, media

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Regulation of Gene Expression in Astrocytes terminally differentiated nor are they as functionally specialized as the oligodendrocytes. Astrocytes ensheathe neuronal dendrites, somas and synaptic surfaces. They also extend processes to the nodes of Ranvier, the pia mater forming the glial limitans, and to all brain capillaries. Thus the astr