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Titlebook: Biologics to Treat Substance Use Disorders; Vaccines, Monoclonal Ivan D. Montoya Book 2016 Springer International Publishing Switzerland 20

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Summary and Critical Reflectionn and Li 2012; Winchell et al. 2012; Donovan et al. 2012), low medication compliance during the conduct of clinical trials (Anderson et al. 2012, 2014; Somoza et al. 2013), and, with few exceptions, the perception by pharma that developing medications to treat SUDs will not provide a favorable retur
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Summary and Critical Reflectionbodies as catalysts for the metabolism of cocaine, researchers produced antibodies against the cocaine itself in human subjects..This cocaine vaccine now has been through late phase II clinical trials. The mechanism of action for this vaccine is to induce antibodies to the cocaine, which act kinetic
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Procedure, Methods and Overview make this enzyme useful for most cocaine abusers. Pharmacological and behavioral procedures for evaluation of compounds of interest exist at both the preclinical and clinical levels. Discovery technology is making great strides toward the development of long-lasting enzyme therapeutics.
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Summary and Critical Reflection vaccine platform using cocaine and nicotine targets. Summaries are provided of the supporting data for efficacy in mice, rats, and non-human primates with phenotypes that include drug biodistribution, drug-induced locomotor behavior, drug self-administration, and positron emission tomography of dru
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