Titlebook: Biologically Based Methods for Cancer Risk Assessment; Curtis C. Travis Book 1989 Springer Science+Business Media New York 1989 assessment

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Spirometry

From Knot Invariants to Knot Dynamics,uch a model should have clear interpretation in biological terms and, if their dependence on dose of environmental agent can be measured or inferred, then the model can be used for low-dose and inter-species extrapolation of cancer risk.

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Synchronism

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https://doi.org/10.1007/978-1-4302-4786-9n. Lacking detailed information on interspecies differences, it is frequently assumed that experimental results can be extrapolated between species when administered dosage is standardized as either mg/kg body weight per day (body weight scaling) or mg/m. per day (surface area scaling). Several inve

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Know and Grow the Value of Your Businessnd similarities between experimental and observed carcinogenesis (‘the mouse-to-man problem’) In this area, two extreme positions can be made out: (1) the ‘optimistic’ one (frequent among regulatory authorities), which accepts a direct “extrapolation” of all kinds of xenobiotic effects from strains

malign

The Hardest Step: Succession Planningthe use of pharmacokinetic models considering relevant metabolic routes may considerably improve risk assessment procedures (Bolt, 1987; Travis, 1987). The biological basis for an appropriate interspecies extrapolation is knowledge of the biochemical mode of action and of the toxicologically relevan

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