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Titlebook: Biologically Active Molecules; Identification, Char Urs Peter Schlunegger Conference proceedings 1989 Springer-Verlag Berlin Heidelberg 198

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期刊全称Biologically Active Molecules
期刊简称Identification, Char
影响因子2023Urs Peter Schlunegger
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图书封面Titlebook: Biologically Active Molecules; Identification, Char Urs Peter Schlunegger Conference proceedings 1989 Springer-Verlag Berlin Heidelberg 198
影响因子Over the past few years there has been a remarkable and rapid development of modern analytical methods, and the fields of nuclear magnetic resonance and mass spectrometry have been no exception. In addition to being able to do "more and faster", new innovative techniques have also arisen to contribute to a growing understanding of the relationship between chemical structure and biological activity. In order to explore a few of the more interesting points of those developments and applications, a seminar "From Biological Activity to Structure" was organized from September 5-7, 1988, at Interlaken. The four invited speakers, Richard M. Caprioli, Howard R. Morris, Wolfgang Steglich and Dudley H. Williams were kind enough to attend and discuss many facets of their research, especially methodological and technical developments and their applications to specific problems. Participants were introduced to continuous flow FAB (fast atom bombardment) and its use, for example, in the real time monitoring of biochemical reactions in vitro and in vivo; the structural elucidation of secondary metabolites from fungi; the analysis of molecule-receptor interactions; the determination of posttransla
Pindex Conference proceedings 1989
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Continuous-Flow Fast Atom Bombardment Mass Spectrometry,molecular biologist for the solution of structural problems. Although FAB has become widely used and has many advantages over other mass spectrometric ionization techniques, it is clear that several disadvantages of the technique severely limit its utility. Generally, these difficulties are a conseq
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The Application of High Mass FAB Mass Spectrometry to Molecular Biology,cular weight substrates - the phenomenon of Molecular Recognition - the processes which give functionality to living systems. A deep understanding of the functions of these macromolecules must depend upon understanding the chemistry of these interactions, which itself demands definition of their str
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Identification of Active-Site in a Neurotoxic Snake Venom by Affinity Labelling and State-of-the-Arlecule were deduced using nanomole quantities of the toxin and utilizing the state-of-the-art fast atom bombardment tandem mass spectrometric techniques. Active-site of the venom was identified by affinity labelling followed by the sequencing of the labelled molecule.
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Peptide Defence Systems, appear to have evolved as toxins find use in medicine. For example, the curare alkaloids, produced by various species of Strychnos and Chondodendron and used as arrow poisons by Indians in the Amazon and Orinoco valleys, are used in small quantities as skeletal muscle relaxants. The search for nove
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Structure-Activity Relationship in Biomembranes Investigated by Infrared-ATR Spectroscopy,olecular level. The technique is optimum if the sample is immobilized in an oriented way. In this paper we report on the formation of lipid bilayer membranes which are then used for interaction studies with local anesthetics and as a support for the oriented adsorption of membrane fragments with inc
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Defining the Process and Planning Phase is given on the structures and activities of some representative lipopeptides. The present knowledge on the biosynthesis of such compounds is reviewed. The biosynthesis of surfactin from .. . ATCC 21332 was studied. An enzyme was isolated and highly purified from a cell-free extract of this organis
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