Titlebook: Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates; W. E. G. Müller,H. C. Schröder Book 1994 Sprin

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D. Hölzel,G. Schubert-Fritschle,Ch. Thiemeons. A restriction of available bioactive dsRNA (or of dsRNA-dependent enzymes) may play an important role in the disease progression. The results summarized in this review show that defects in dsRNA-dependent pathways exhibited by AIDS patients can be reversed, at least in part, by exogenously supplied dsRNA.

Affection

https://doi.org/10.1007/978-3-7091-9188-0e, 2- and 8-azido analogs of 2-5A to RNase L, and azido dsRNAs to 2-5A synthetase and p68 kinase is described. In addition, the newly discovered role of the 2-5A molecule as an inhibitor of HIV-l reverse transcriptase (RT) is discussed.

uncertain

Activation of the dsRNA-Dependent Kinase,to a functional enzyme, and in some cases prevention of its activation, is dependent on RNAs containing accessible double-stranded structures. However, like several other protein kinases, once activated, it elicits a modulating effect that alters cellular processes.

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Photolabeling of the Enzymes of the 2-5A Synthetase/RNase L/p68 Kinase Antiviral Systems with Azidoe, 2- and 8-azido analogs of 2-5A to RNase L, and azido dsRNAs to 2-5A synthetase and p68 kinase is described. In addition, the newly discovered role of the 2-5A molecule as an inhibitor of HIV-l reverse transcriptase (RT) is discussed.

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