Titlebook: Biological Reactive Intermediates—II; Chemical Mechanisms Robert Snyder,David J. Jollow,Stephen L. Longacre Book 1982 The Editor(s) (if ap

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The Heme Protein P-450 in Oxygen Activation: Carbon Monoxide Inhibition and Photochemical Action Speminantly in the inner membranes of the mitochondria of endocrine organs catalyze a variety of oxygenating processes which operate on many different endogenous (e.g. steroids, bile acids) as well as foreign compounds (e.g. drugs, pesticides, toxic chemicals, chemical carcinogens, and other xenobiotic

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Possible Mechanism of Coupled NADPH Oxidase and P-450 Monooxygenase Actione an intermediate in the NADH-supported electron transfer pathway (Sasame et al., 1973; Hrycay and Prough, 1974; Hrycay and Estabrook, 1974; Lu et al., 1974; Jansson and Schenkman 1975, 1977). Less clear is the role of cytochrome .. in the NADPH-supported and NADH-synergized reactions. This synergis

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Studies on the Mechanism of Stimulation of Microsomal H2O2 Formation and Benzo(a)pyrene Hydroxylatonflavone of microsomal hydroxylation of benzo(a)pyrene and its inhibition by catalase and methanol suggests but does not prove a necessary interaction of microsomal H.O. production with benzo(a)pyrene hydroxylation..Hexobarbital and flavone-stimulated H.O. formation is optimal at a stoichiometric rel

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Relationship between Benzene Metabolism and Toxicity: A Proposed Mechanism for the Formation of Reacing leukopenia, pancytopenia, bone marrow hypoplasia or aplasia, thrombocytopenia, granulocytopenia and lymphocytopenia (Aksoy et al, 1971; 1972 Goldwater, 1941; for review see Laskin & Goldstein, 1977). Among these abnormalities one of the most frequently cited is lymphocytopenia. In one of the few

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Introduction