Titlebook: Biological Modulation of Solid Tumours by Interferons; Karl Pummer Conference proceedings 1994 Springer-Verlag Berlin Heidelberg 1994 Biol

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Von der Parteien- zur Mediendemokratie,lium of the normal and malignant breast. These biologicals can exert a direct antiproliferative effect on cells, modulate the secretion of growth factors by a tumour, or increase the immune defenses of the host. The strategies employed for the clinical development of these biologicals rely on an in-

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Kleinparteien in der Mediendemokratie0 months with less than 10% of patients surviving for 2 years [1]. This poor prognosis depends on the fact that conventional therapy is ineffective, with an objective response rate of less than 20% for hormonal and chemotherapeutic agents given either alone or in combination [2]. These disappointing

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978-3-642-78868-0Springer-Verlag Berlin Heidelberg 1994

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Biomodulation of 5-Fluorouracil by Interferon-Alpha,offers little benefit as a single agent. Response rates in colon cancer, for example, range from 7% to 25%. When patients do achieve an objective response, the duration is generally short, and complete responses are uncommon.

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Kleinparteien in der MediendemokratieHead and neck cancer accounts for approximately 7% of all incident malignant neoplasms worldwide, and tumours of the mouth and pharynx alone represent the fourth most frequent malignancy in males [1].

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