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Titlebook: Biological Mechanisms of Minimal Residual Disease and Systemic Cancer; Julio A.‘Aguirre-Ghiso Book 2018 Springer Nature Switzerland AG 201

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期刊全称Biological Mechanisms of Minimal Residual Disease and Systemic Cancer
影响因子2023Julio A.‘Aguirre-Ghiso
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发行地址Provides unprecedented insight into the biology of MRD dormancy and metastasis initiation in solid cancers.Brings together a unique comparative review of technologies used to detect MRD in solid cance
学科分类Advances in Experimental Medicine and Biology
图书封面Titlebook: Biological Mechanisms of Minimal Residual Disease and Systemic Cancer;  Julio A.‘Aguirre-Ghiso Book 2018 Springer Nature Switzerland AG 201
影响因子.This book focuses on the biological mechanisms of minimal residual disease (MRD) and recurrence. It integrates this biology in solid cancers and in hematological malignancies. It reports also on technological advancements for monitoring MRD, derived from mechanistic insights. Chapters in solid and hematological malignancies address stem cell biology, genetics, epigenetics and micro-environmental regulation of dormant MRD. Novel insight into technologies for molecular phenotyping of MRD and monitoring of CTCs, DTCs and cell free RNA and DNA are also addressed extensively... ..Five chapters explore the above concepts in solid cancers such as prostate, breast, melanoma, head and neck and esophageal. Two chapters also explore the basic mechanisms of vascular biology targeting and epigenetic mechanisms regulating pluripotency programs during dormancy. Similar biology is explored in hematological malignancies such as T-ALL, CML, AML and multiple myeloma in additional four chapters.   .. ..This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman,
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Minimal Residual Disease in Prostate Cancer,ence, but has not yet been routinely used in clinical care. Investigators have detected MRD by identification of prostate cancer cells in the bone marrow; termed disseminated tumor cells (DTCs) and blood; termed circulating tumor cells (CTCs). Various techniques including PSA-RT PCR, PSA immunocytoc
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Detection of Minimal Residual Disease and Its Clinical Applications in Melanoma and Breast Cancer Ponitoring for minimal residual disease (MRD) during a disease-free follow-up period would greatly improve patient outcomes through earlier detection of relapse or treatment resistance. However, MRD monitoring in solid tumors such as melanoma and BC are not well established. Here, we discuss the clin
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Minimal Residual Disease in Multiple Myeloma: Impact on Response Assessment, Prognosis and Tumor Hel response exceed 90% and complete response (CR) more than 50% in some studies. Unfortunately, despite higher rates of CR, relapse rates remain high suggesting that persistent disease may not be measured by current techniques. Traditionally, response rates were defined by urine and serum protein ele
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