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Titlebook: Biological Effects of 224Ra; Benefit and Risk of W. A. Müller,H. G. Ebert Conference proceedings 1978 ECSC, EEC, EAEC, Brussels-Luxembourg

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The Dependence of late effects in mice on the temporal distribution of skeletal α-doses from 224Ra a female NMRI mice 4 weeks old at the start of the experiment. Their mean spontaneous osteosarcoma incidence is 0.7%. Osteosarcomas of the jaws were excluded from the evaluation or considered separately. The radionuclides were injected intraperitoneally as isotonic solutions..Dosimetric data for .Ra
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https://doi.org/10.1007/978-3-663-02621-1sarcoma occurrence in mice under conditions of comparable time course of the mean skeletal dose from repeated .Ra or single .Ra injections; .Ra was found to be three to four times more efficient than .Ra in the region of comparable doses. The evaluation of the role of the differences in soft tissue
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https://doi.org/10.1007/978-3-663-02621-1ed in the group of control mice..The presented experimental findings seem to lead to a general conclusion that, at the same skeletal dose, the relative radiotoxicity of .Ra is about 4 times higher than the toxicity of .Ra. The possibility of how to compare experimental results obtained in various la
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Mechanistische Weltauffassung und Erfahrungde by repeated injections every 3.5 days. The maximum osteosarcoma incidences observed in this series were 84% (total mean skeletal dose 2160 rad, maximum dose rate 24 rad/day, treatment period 24 weeks) and 93% (total mean skeletal dose 1080 rad, maximum dose rate 8 rad/day, treatment period 36 wee
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Quality control in the production process and purity of 224Ra for injectiond..We compare the detected long-lived radioactive impurities in 280 μCi .Ra injection-solutions with the maximum values accepted by ICRP. The actual amounts of impurities present are less than 0,2% of the permissible doses recommended by ICRP..The .Ra solution is sterilised in an autoclave to a stan
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