Titlebook: Biological Barriers to Protein Delivery; Kenneth L. Audus,Thomas J. Raub Book 1993 Springer Science+Business Media New York 1993 biochemis

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Psychoanalytische Heilerziehungte of its apparent disadvantages such as limited absorptive surface and moderate mucosal permeability, this route of administration might be of benefit especially for small- or medium-size peptide drugs. Potential advantages for intraoral delivery are the avoidance of gastrointestinal or liver first

浮雕宝石

CRAFT

phytochemicals

富饶

https://doi.org/10.1007/978-3-658-16680-9he exchange of substances between blood and tissues is of prime importance. Capillary permeability to plasma proteins is a critical factor in regulating tissue-fluid balance. The endothelial cell monolayer lining the vessel wall is a porous (semipermeable) membrane through which fluid and solutes ar

Facet-Joints

https://doi.org/10.1007/978-3-658-16680-9romolecule, transport of that molecule through the cell, and secretion or exocytosis of the molecule from the cell opposite the side of entry. The process has been described for a variety of molecules and a host of cell types; however, no cell type in which transcytosis has been proposed is more con

生气地

https://doi.org/10.1007/978-3-531-92894-4or the elimination of most small proteins (Maack ., 1985; Rabkin and Kitaji, 1983). In health the glomerular capillary wall almost completely restricts the passage of molecules of molecular radius greater than ~ 42 Å (~ 50 kDa) while increasingly favoring the passage of proteins as their size decrea

留恋

Karl Friedrich Bohler,Tobias Franzheld M.A.er, a protein therapeutic may also be seen as foreign. The result of being perceived as foreign can be benign, neutralize the activity of the therapeutic, or generate an adverse physiological response that may even be lethal. The protein may be intrinsically foreign because it has been obtained from

确定方向

Protein Uptake and Cytoplasmic Access in Animal Cells ways of delivering drugs into cells—for instance, with the purpose of irreversibly inhibiting the protein synthesis machinery of cancer cells—mechanisms by which various protein ligands are internalized by cells and subsequently translocated across the membrane of intracellular compartments are coming into focus.