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Titlebook: Bioinformatics for Systems Biology; Stephen Krawetz Book 2009Latest edition Humana Press 2009 Ensembl.Gap.GoPubMed.In silico.Microarray.T-

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发表于 2025-3-21 16:06:51 | 显示全部楼层 |阅读模式
期刊全称Bioinformatics for Systems Biology
影响因子2023Stephen Krawetz
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图书封面Titlebook: Bioinformatics for Systems Biology;  Stephen Krawetz Book 2009Latest edition Humana Press 2009 Ensembl.Gap.GoPubMed.In silico.Microarray.T-
影响因子.The biological sciences are now in the midst of a true life sciences revolution akin to what physics experienced just after the turn of the last century. We are now in a phase of unparalleled growth that is reflected by the amount of data generated from each experiment. At the time of this writing, the rate of data acquisition was approaching 2 terabytes over the course of 5 days with first pass analysis proceeding over the following 2-3 week period. This fundamental shift has provided unprecedented opportunities that for the first time afford us the ability, i.e., means, breadth, and depth of data, to truly address human biology at the systems level. This wealth of information from seemingly disparate datasets and its integration is being realized through bioinformatics. It is with this philosophy that the text Bioinformatics for Systems Biology was born. This revolution has spawned true personalized medicine that encompasses diagnostics and treatment through to cure. ..For the physical and computer scientist, this text provides an introduction to the basic biological principles governing a cell. This quickly moves from the fundamentals to exploring the underlying genetic process
Pindex Book 2009Latest edition
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DNA Replication, Recombination, and Repairnsmission of this information to the progeny and protection of the genome from chemical degradation are essential to life. Complementary base pairing in duplex DNA provides an elegant means for accurate replication of DNA and repair of DNA damage. Each strand of the duplex provides a template for ge
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Cell Signalinge signaling pathways are duration and magnitude of the input and subsequent biological responses. Key features of signaling processes include the time- and dose-dependent responses mediated by downstream molecular effectors. The precision of signaling is accomplished through negative feedback and br
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Epigenetics of Spermiogenesiss. Indeed, after meiosis, early male haploid cells, or spermatids, inherit a somatic-like chromatin-based genome organization. In the following stages of their maturation, histones are removed and replaced by testis-specific basic proteins, while their genome undergoes a dramatic compaction. Despite
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Probability and Hypothesis Testingting. Examples of the use of the binomial theorem and Fisher’s exact in associating gene expression with observed outcomes (i.e., disease) are presented. A brief introduction to the concepts of hypothesis testing, power, ROC (receiver-operating curves) and sensitivity and specificity are also presen
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Stochastic Models for Biological Patternstationally simple IID models is followed by a discussion on the Markov models for sequences. Similarly, discussions on pattern models focused on the theoretical background of Position Specific Scoring Matrices and Profiles for representation of biological sequence patterns. A detailed discussion and
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Population Geneticss the forces that cause or maintain these exchanges. This exchange of genes and alleles causes changes in the specific allele and hence genotype frequencies within and between populations. Studying this evolution helps us to better understand how to use human populations as a data set to clarify gen
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