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Titlebook: Bioinformatics and Systems Biology; Collaborative Resear Frederick B. Marcus Book 2008 Springer-Verlag Berlin Heidelberg 2008 Bioinformatic

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Systems Biologyidered, followed by analysis of the key p53 gene for apoptosis control and an analysis of the key process of spindle formation and related imaging techniques. Signalling and control are at the heart of systems biology analysis, and this is considered in detail for metabolic regulation. The circadian
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Databases, Computational Tools and Services and grids, in terms of databases, bioinformatics and systems biology tools and services. Many of them are available via major centres and gateways such as the European Bioinformatics Institute; others are available via distributed and often cross-linked resource centres. Tools such as the Distribut
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Infectious and Major Diseasesng viral and bacterial pathogens, cardiovascular—pulmonary diseases, diabetes and neurological disease. Cancer, with its special genetic characteristics, is discussed separately in .. The immune system is examined to understand in role in both healing processes and disease. Many aspects of the resea
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Cancerause of its extreme genetic diversity and multistage complexity. Nevertheless, there are many common themes which are explored here. The nature of cancer is reviewed, and then systematically explored, considering in turn the roles of tumour viruses, cellular oncogenes, growth factors and their recep
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Science Managementearch depends on people, their needs and motivations, the institutional and legal and management frameworks. Otherwise collaborative research degenerates into a funding envelope with individual researchers following separate lines of research. The way in which the European Commission Framework Progr
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Perspectives the extreme complexity of living systems means that it is important to have longer-term perspectives to see how knowledge may be accumulated, interpreted and exploited as strategically and as usefully as possible, and to see what resources need to be developed to support these advances. A number of
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Outstanding Results and Conclusions are often crucial to understanding and advances in a particular field. These results emphasise that collaborative research has had major successes, and that in many ways it has transformed life science research. Impact is judged in terms of greatly increasing the capabilities of biomedical research
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