Titlebook: Bioinformatics and Drug Discovery; Richard S. Larson Book 2006 Humana Press 2006 In silico.Radiologieinformationssystem.bioinformatics.dev

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Discovering New Drug-Targeting Sites on Flexible Multidomain Protein Kinases,ts and crevices detected around the dynamic domain-domain interface provide new targeting sites for tethered-based extension of current small-molecule lead compounds to produce more potent and selective pharmaceutical agents.

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, Protein Design,re packages have been developed for . protein design. The methods for selecting the protein structure, defining the portion to be designed, and choosing the input parameters for the software are described in this chapter.

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New Strategies in Drug Discovery,central to the drug discovery process. The ability to associate a specific gene with a disease can be attributed primarily to the extraordinary progress that has been made in the areas of gene sequencing and information technologies. Selection and validation of novel molecular targets have become of

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From Microarray to Biological Networks,ety of metabolic, xenobiotic, or pathogenic challenges. This potentially vast quantity of data enables, in principle, the dissection of the complex genetic networks that control the patterns and rhythms of gene expression in the cell. Here we present a general approach to developing dynamic models f

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Microarray Analysis in Drug Discovery and Clinical Applications,r summarizes some of these applications such as identification and validation of anti-infective drug target, study mechanisms of drug action and drug metabolism, classification of different types of tumors, and use of molecular signatures for prediction of disease outcome. A step-by-step protocol is

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Standardization of Microarray and Pharmacogenomics Data,andards. Various file format standards were soon developed to convey increasingly complex and voluminous data that nomenclature alone could not effectively organize without additional structure and annotation. As areas of biochemistry and molecular biology have become more integral to the practice o

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