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Titlebook: Bioinformatics Research and Applications; 13th International S Zhipeng Cai,Ovidiu Daescu,Min Li Conference proceedings 2017 Springer Nature

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Theorie und Praxis der Diskursforschung, and evolutionary conservation. The results we present support the use of surface images as a new type of family-specific signatures in functional annotation and drug-binding tasks. We demonstrate the ability of our method to detect local surface similarities between proteins and to correctly identify functional classification of proteins.
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https://doi.org/10.1007/978-3-8348-9620-9d to mine .-mers of various lengths termed .-. via inverted-index technique, which is orders of magnitude faster than the conventional forward-index method. Moreover, to the best of our knowledge, VLmer is the first able to mine .-mers of various lengths in both DNA and protein sequences.
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Unfolding the Protein Surface for Pattern Matching,, and evolutionary conservation. The results we present support the use of surface images as a new type of family-specific signatures in functional annotation and drug-binding tasks. We demonstrate the ability of our method to detect local surface similarities between proteins and to correctly identify functional classification of proteins.
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Mapping Paratope and Epitope Residues of Antibody Pembrolizumab via Molecular Dynamics Simulation,, LYS78 and ALA132 on PD-1) were found to play critical roles in the interaction of PD-1 and PD-L1. Therefore, pembrolizumab prevents PD-L1 from interacting with PD-1 through steric hindrance, and the key residues sorted out here were potential hotspots for the optimization of pembrolizumab.
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