Titlebook: Bioinformatics Methods in Clinical Research; Rune Matthiesen Book 2010 Humana Press 2010 Annotation.Anästhesie-Informations-Management-Sys

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Ellen Hoffmann,Gerhard Steinbeckny contexts and disciplines. Cluster analysis encompasses different methods and algorithms for grouping objects of similar kinds into respective categories. In this chapter, we describe a number of methods and algorithms for cluster analysis in a stepwise framework. The steps of a typical clustering

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https://doi.org/10.1007/978-3-642-72520-3er at the molecular level have arisen from microarray data. Molecular profiling has supported the notion that breast cancer is not a simple disease with a single tumorigenic pathway but a rather heterogeneous one. Gene expression studies have identified and validated the existence of different breas

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Katheterdiagnostik via Arteria femoralisg functions, search strategies have received less attention, and an accurate description of search algorithms is limited. Proteomics is becoming more and more commonly used in potential clinical applications; for such approaches to be successful, the combinatorial problems from amino acid modificati

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Geschichte der Herzkatheteruntersuchung,s spectra has aroused tremendous interest in the last few years. In spite of its potential for biomarker discovery, it is recognized that the identification of meaningful proteomic features from mass spectra needs careful evaluation. Hence, extracting meaningful features and discriminating the sampl

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https://doi.org/10.1007/978-3-642-47591-7amples of clinical relevance. Although considered to have a low throughput, 2D gels can separate thousands of proteins in one gel, making it a good complementary method to MS-based protein quantification. The main drawback of the technique is the tendency of large and hydrophobic proteins such as me

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,Punktion voroperierter Gefäße, cell death in cancer cells but not in normal cells. Therefore, the development of histone deacetylase inhibitors for the treatment of various cancers has gained tremendous interest in recent years, and many of these inhibitors are currently undergoing clinical trials. Despite intense research, howe