Titlebook: Bioengineering and Cancer Stem Cell Concept; Mirjana Pavlovic,Bela Balint Book 2015 The Author(s) 2015 Bioengineering of tumors.Bioinforma

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https://doi.org/10.1007/978-3-319-25670-2Bioengineering of tumors; Bioinformatics; Antitumor therapy; Cancer stem cell; Genetics; Epigenetics; Mark

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Mirjana Pavlovic,Bela BalintIncludes supplementary material:

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crucial

BRIBE

Kundenorientierte Softwareproduktiond differentiation. A complex network of interactive substances and factors organize and protect the survival of toti/pluri/multipotent SC, maturation (differentiation), and multiplication (proliferation). Namely, differentiation and proliferation of SCs in the bone marrow (BM) are regulated by the e

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Eva Thelen,Oliver Koll,Hans Mühlbacher and their use in development of novel targeted antitumor therapy. It was difficult to prove the CSCs existence, unless the in vivo and in vitro experiments have been done supporting the theory that they have common clonogenic origin and perpetuate always the same phenotypic marker(s) on their surfa

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Eva Thelen,Oliver Koll,Hans Mühlbacherin DNA methylation, histone modifications, polycomb, miRNAs, and chromatin remodeling complex function are mechanisms that directly contribute to tumorigenesis. However, this chapter will summarize the most relevant genetic alterations, which contribute to the regulation of cancer stem cell features

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CRM - Grundlagen und Erfolgsfaktorenord blood, and induced pluripotent stem cells (IPSC)). However, the particular mitochondrial function in cancer stem cells is still under investigation. Self-renewal capacity and pluripotency are the essential features of stem cells. Several tissue stem cells (for example, long-term hematopoietic st