Titlebook: Biochemistry of Chemical Carcinogenesis; R. Colin Garner,Jan Hradec Book 1989 Plenum Press, New York 1989 Colon.DNA.Glutamat.Glutamin.bioc

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Interactions of Carcinogens with Nucleic Acids,bing these interactions, identifying the chemical structures of the DNA adducts, studying their enzymic removal, the biological consequences and correlating extents of adduction with carcinogenic response. The majority of these studies have been centred on experimental models and only a few on man,

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Functional Significance of Ribonucleic Acids Modified by Chemical Carcinogens: A Review,llular genome and may thus lead to malignant transformation. Besides DNA, carcinogens are known to react also with proteins and RNA. It has been stated that RNA has even a greater propensity for the covalent reaction with carcinogens than DNA. Of various species of RNA, tRNA seems to be most frequen

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Evaluation of Carcinogenic and Non-Carcinogenic Metal Compounds by Their Interference in the Renatuher fail to do so or even assist in its renaturation. The carcinogenic metals tend to keep the DNA unravelled when its two strands are annealed from around 80. to 2.C as studied by U.V. spectrophotometry. Studies on the interactions of carcinogenic metals with nucleic acid based have further reveale

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Chemical Carcinogens and Oncogenes,cer among human populations and its prevalence in individuals with specific occupations and habits has provided important clues on the etiology of the disease. Studies on the metabolism of potent chemical carcinogens in different cell types have identified active derivatives of many of these compoun

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P21 Level and Tyrosine Kinase Activity during Carcinogenesis of Human Colon Tumors,inomas by quantitative immunohisto chemistry. The level of tyrosine kinase activity in 27 colon carcinomas has also been evaluated. Elevated level of . p21 could be detected in the hyperplastic and dysplastic lesions, in 32% of colon adenomas and 52% of colon carcinomas. A strong correlation could b

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Utilization of Initiator Transfer Ribonucleic Acid Modified by Carcinogens Cholesteryl 14-Methylhexetitively inhibited by .-methyl-.-nitrosourea which has been previously demonstrated to alkylate guanine. It thus appears that the lipid reacts with guanosine residues in the molecule of tRNA.. Initiator tRNA preparations pretreated with cholesteryl 14-methylhexadecanoate were charged significantly

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Effect of Thiram on Cytochrome P-450 Studied by the Cypia-Test,0 [the phenobarbital (PB)-3-methylcholanthrene (3-MC)-type) induced by thiram, a dithiocarbamate fungicide. The test consisted of studies by the technique of Ames for the ability of the S-9 preparation obtained from livers of rats induced by thiram to cause metabolic activation of ethidium bromide (

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Translocation of Phosphatidate Phosphohydrolase from the Cytosol to Microsomal Membranes is Increasl to the microsomal membranes was assayed in liver homogenates from long-term thioacetamide-treated rats (100 mg/Kg body weight, daily for 90 days). The translocation of phosphatidate phosphohydrolase induced by oleate was higher (two fold) in liver homogenates obtained from thioacetamide-treated ra

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