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Titlebook: Biochemistry for Anesthesiologists and Intensivists; Fernando Alemanno Book 2020 Springer Nature Switzerland AG 2020 cerebral edema.shock.

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,Glutamate – GABA Collateral Cycle,Transformation of glutamate, one of the most potent exciter neurotransmitters, into Gamma-aminobutyric acid (GABA), one of the most potent inhibitors; the action of vitamin B6 as a coenzyme, as well as antiemetic; the functions of magnesium; and sodium gamma-hydroxybutyric acid (GHB) are described.
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Hexose-Monophosphate Shunt or Horecker Cycle (The Sleep Pathway),The pentose cycle or direct oxidative pathway (DOP) may be defined as the sleep and synthesis pathway. It produces NADPH., fatty acids, amino acids, nucleotides, hormones, nucleic acids, CoA, FAD and so on; the synthesis of glucuronic acid and hyaluronic acid is considered..
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,Blood–Brain Barrier,Blood–brain barrier characteristics are analyzed, which must be considered to be much more than a connective supporting tissue between the neurons and the capillary endothelium.
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Shock,Pathogenesis of shock and its treatment are considered. We warn against the excessive use of catecholamines (apart from septic shock).
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Cerebral Oedema,Pathogenesis of cerebral oedema is considered. We also consider the various therapeutic measures available: mannitol, glycerol, dihydroxyacetone, hypertonic saline solution, barbiturate coma, cortisones, citicoline. An original technique of infusion via the carotid artery is illustrated.
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Pulmonary Surfactant,Pulmonary surfactant composition and Laplace’s formula are explained.
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When the Mind Does Not Work as It Should,The authors consider the possible correlations between certain alterations of the neurotransmitters of the central nervous system and two common clinical syndromes: schizophrenia and depression.
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Normobaric Oxygen Therapy,,Normobaric oxygen therapy is easy to administer in stay wards with a face mask. It has many effects: antibacterial action; anti-oedema effect; repairs soft tissues; stimulates the activity of the osteoblasts.
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