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Titlebook: Biochemistry and Molecular Genetics of Cancer Metastasis; Proceedings of the S Karoly Lapis,Lance A. Liotta,Alan S. Rabson Conference proce

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Karyotypic Progression and Metastasis Formation of Human Tumorse work from many laboratories, four general statements can be made about karyotypic alterations in neoplasia: 1) most tumors have chromosome abnormalities, which are not present in other cells of the body, 2) in a given tumor, all the neoplastic cells often have the same cytogenetic change, or relat
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Morphological and Functional Alterations of Occludens, Adherens, and Gap Junctions in Cancerbute an equal part. A number of different types of cell junctions, customarily subclassified on the basis of their ultrastructure, have been identified: adherens, occludens, and gap junctions (1,2). These junctions perform the following functions (1–4): (1) They provide strong intercellular adhesion
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Gene Products of the Major Histocompatibility Complex Control the Metastatic Phenotype of Tumor Cellrating basement membranes of blood of extravasating while manifesting, in many cases, specific recognition of target organs, and of inducing angiogenesis essential for the growth of metastasis. Since the local tumor cell population was shown to be diverse with respect to the metastatic competence of
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Biological Response Modifiers for the Therapy of Metastases for the treatment of tumor metastases (1). Several biological response modifying approaches were discussed in detail in other manuscripts in this proceedings. Therefore, the emphasis here will be on alternative approaches which have yielded promising results.
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Integral Membrane Adhesion Glycoproteins: What is their Fate During Metastasis? repertoire of adhesive molecules. In several well-documented situations, it is clear that the repertoires of different tissue types are distinct. For example, nervous tissue expresses calcium dependent and independent cell-cell adhesion molecules that are distinguishable from analagous molecules ex
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