Titlebook: Biochemistry and Molecular Biology of Vitamin B6 and PQQ-dependent Proteins; Ana Iriarte,Marino Martinez-Carrion,Herbert M. Kag Conference

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Physiological Importance of Pyrroloquinoline Quinoneell responsiveness to mitogens, mitochondrial function and reproductive outcome in mice. PQQ is easily absorbed and efficiently taken up by cultured cells. Consequently, a case can be made that PQQ may have physiological importance in animals.

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Lysyl Oxidase Activates the Transcription Activity of Collagen III Promoter: Possible Involvement ofity Shift Assay showed a binding activity in the region from –100 to -76, that was significantly increased by lysyl oxidase over-expression. We identified the binding activity as Ku antigen. The study suggests a new co-ordinated mechanisms that might be critical for the development of fibrosis.

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TGF-ß1 Regulation of Gingival Lysyl Oxidase and Connective Tissue Growth Factor, but TGF-ß and CTGF appear to promote collagen accumulation by mostly independent mechanisms in human gingival cells. In addition, preliminary studies demonstrating the presence of CTGF in oral tissues are discussed.

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Fakten und Normen im Zusammenspiel,partially account for the increase in the activities in serum observed in some treated patients. Interestingly, fibrates down-regulate these genes in the rat, suggestingthat there ae important differences in the regulation of gene expression between rodents and humans.

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