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Titlebook: Bioassay Methods in Natural Product Research and Drug Development; Lars Bohlin,Jan G. Bruhn Book 1999 Springer Science+Business Media Dord

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The Future Role of Natural Products in Drug Discovery, protection in the next 5 years. Never before have so many important drugs come off patent in such a short period of time and the major pharmaceutical companies are racing to find new drugs to replace the billions of dollars in sales they stand to lose.
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The use of Receptor Binding, a Very Specific, High Capacity Screening Method, in the Identificatione broad term ‘combinatorial chemistry’ result in an unprecedented output of new compounds which are subjected to high throughput screening procedures. Thus, natural product research is obliged to make use of these new possibilities, or is doomed to fade away.
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Natural Products with Antiprotozoal Activity,lso made an important impact. The polyene antibiotic ionophores monensin, lasalocid, narasin and salinomycin, are widely used in the prophylaxis of avian coccidiosis, and amphotericin B, is given in the treatment of leishmaniasis and some forms of amoebiasis. The aminoglycoside-aminocyclitol paromom
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B. B. Zhou,R. P. Brent,D. Walsh,K. Suzakilso made an important impact. The polyene antibiotic ionophores monensin, lasalocid, narasin and salinomycin, are widely used in the prophylaxis of avian coccidiosis, and amphotericin B, is given in the treatment of leishmaniasis and some forms of amoebiasis. The aminoglycoside-aminocyclitol paromom
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