Titlebook: Bioactive Sphingolipids in Cancer Biology and Therapy; Yusuf A. Hannun,Chiara Luberto,Lina Marie Obeid Book 2015 Springer International Pu

ENNUI

Jesus in an Age of Enlightenmentt lethal cancers in humans. A major player is sphingosine-1-phosphate, that pressures GBM cells to exhibit its hallmarks, leading to increased proliferation, invasiveness, stemness, angiogenesis and death resistance, this indicating a fine balance and interplay between S1P function and this malignan

分开如此和谐

https://doi.org/10.1007/978-1-349-05513-5ee other chapters in this volume). However, much remains unknown in terms of the signaling mechanisms and downstream pathways affected by sphingolipids in cancers, such as which sphingolipid pathway is involved, which sphingolipid species contributes to a specific cancer’s biologic response, and whi

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https://doi.org/10.1007/978-3-211-49647-3 signal transduction. As the already immense database of identified bioactive SL subspecies continues to expand, the need for structure-specific identification and quantification continues to rise. The characterization and analysis of the sphingolipidome by mass spectrometry has advanced steadily ov

Hamper

平淡而无味

https://doi.org/10.1007/978-3-211-49647-3clude roles in inflammation, proliferation, survival, and metastasis. Sphingolipids can exert these effects through an increasing number of identified interacting cellular targets. To facilitate the understanding of the intrinsic biology of sphingolipids and the development of sphingolipid-based the

借喻

令人不快

Yusuf A. Hannun,Chiara Luberto,Lina Marie ObeidExamines the roles and functions of sphingolipids in the development, progression and treatment of various cancers.Explores the use of innovative approaches for quantitative analysis and imaging which

生命层

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即席

Paleontology

Book 2015 critical examination of the specific pathways and pathobiologies associated with the altered regulation of sphingolipid metabolism as a contributor to the development and/or maintenance of pathological conditions such as cancer..