Titlebook: Bioactive Conformation II; Thomas Peters Book 2008 Springer-Verlag Berlin Heidelberg 2008 Lipid.RNA.analytical chemistry.biochemistry.chem

OCTO

希望

Domino-Objekt- und Speichermodelleceptors and the distinct enzymes involved in bacterial resistanceare consistent with this view. This conformational diversity can, in certain favorable cases, be exploitedin the design of new antibiotic derivatives not susceptible to enzymatic inactivation, by designing tailor-madeconformationally locked aminoglycosides.

流动性

合同

Studies on the Conformational Features of Neomycin-B and its Molecular Recognition by RNA and Bacteeceptors and the distinct enzymes involved in bacterial resistanceare consistent with this view. This conformational diversity can, in certain favorable cases, be exploitedin the design of new antibiotic derivatives not susceptible to enzymatic inactivation, by designing tailor-madeconformationally locked aminoglycosides.

烦人

AGOG

NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands, transduction pathways, rely on the subtle interactionsbetween atoms at the binding interface of the involved molecules. Because biomolecules often havemany interacting partners, these interactions are not necessarily strong. The study of molecularrecognition gives insight into the complex network o

渐强

放逐

,Structural and Functional Studies of Peptide–Carbohydrate Mimicry, to anti-carbohydrate antibodies, carbohydrate-processingenzymes, and lectins have been identified. These peptides are potentially useful as vaccines andtherapeutics; for example, immunologically functional peptide molecular mimics (mimotopes) can strengthenor modify immune responses induced by carb

neoplasm

Studies on the Conformational Features of Neomycin-B and its Molecular Recognition by RNA and Bactey, with different conformations, even .ones, in fast exchange. Very probably, this feature allows the adaptation of these ligands to the spatialand electronic requirements of different receptors. The large diversity of structures adopted by aminoglycosidesin the binding pocket of the different RNA r

olfction

,Modulation of the Bioactive Conformation of Transforming Growth Factor β: Possible Implications of involve numerous cytokines, acting throughcorresponding sets of cell-surface receptors. The transforming growth factor β (TGF-β)superfamily includes a variety of structurally related multifunctional cytokines that play criticalroles in maintaining cellular homeostasis and controlling cell fate. Res