Titlebook: Bio-orthopaedics; A New Approach Alberto Gobbi,João Espregueira-Mendes,Mustafa Kara Book 2017 Springer-Verlag GmbH Germany, part of Springe

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The Use of a Large Animal Model and Robotic Technology to Validate New Biotherapies for ACL Healings a replacement. The results of ACL reconstruction have been successful for many patients as it can restore joint stability and relieve pain. However, longer term follow up studies have shown unsatisfactory outcomes with as many as 25% of patients having complications that include prevalence of oste

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Stem Cells in Joint Repairchondrocyte implantation (ACI) has been proven to restore hyaline-like articular surface, which is mechanically and functionally stable even in athletes at long-term follow-up. However, despite the breakthrough merit of the original procedure, it showed some issues such as local morbidity for perios

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https://doi.org/10.1007/978-1-349-21284-2opment of biological substitutes that restore, maintain, or improve tissue function or a whole organ [1]. The strategies of tissue engineering or in other words “regenerative medicine” require both relation and communication of cells with tissue by signaling pathways [1–3].

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Tissue Engineering and New Biomaterialsopment of biological substitutes that restore, maintain, or improve tissue function or a whole organ [1]. The strategies of tissue engineering or in other words “regenerative medicine” require both relation and communication of cells with tissue by signaling pathways [1–3].

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https://doi.org/10.1007/978-3-030-31030-1basic for the success when regenerating are controlled by signalling molecules. The biological pathways are immediately activated after a tissue injury, using the Growth Factors we are capable of modulate this response. They are involved in biological functions, such as cellular proliferation, cellular survival, migration and even apoptosis.