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Titlebook: Beyond Our Genes; Pathophysiology of G Raffaele Teperino Book 2020 Springer Nature Switzerland AG 2020 gene.health.disease.environment.epig

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Environmental Factors’ Interference in Endocrine Aspects of Male Reproductionconsequently resulting in weight gain and contributing to obesity epidemic. Obesogens can regulate hypothalamic-pituitary-gonadal axis function at different levels within different critical windows of exposure, with different concentration-dependent intensity, and with multiple mechanisms of action
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Gene-Environment Interaction and Individual Susceptibility to Metabolic Disorders 2 diabetes (T2D). It is well-established that environmental factors have a major impact on obesity and to some degree on T2D. This chapter focuses on the genetic causes of obesity and T2D, and the potential interactions with environmental and behavioral factors which may contribute to the ongoing i
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Gene-Environment Interaction and Cancerpermethylation, altered histone methylation and acetylation and dysregulation of miRNAs have been shown in several types of cancers. Epigenetic events are susceptible to environmental and lifestyle factors, including diet, endocrine disruptors and circadian rhythm. Nutrition is thought to be the mos
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The Role of Gene-Environment Interaction in Mental Health and Susceptibility to the Development of Pield of psychiatric genetics, with a special focus on research from molecular genetic studies. The chapter starts with a review of GxE studies of mental health disorders which includes both recent genome-wide GxE studies, as well as candidate gene studies, since the latter comprise the majority of s
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Gene/Environment Interaction and Autoimmune Diseasely impact the quality of life of those afflicted by them with no cure currently available. The exact etiology of autoimmune diseases is not completely clear. Biomedical research has revealed that both genetic and environmental factors contribute to the development and progression of these diseases.
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Introduction to Epigenetic Inheritance: Definition, Mechanisms, Implications and Relevanceic inheritance has shown that individual’s environmental experiences can influence developmental and phenotypic trajectories across several generations. The field is now starting to unveil the molecular mechanisms, while its relevance for complex disease risk and adaptive evolution is still unclear
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Future Perspectives in Epigenetic Inheritancerlying molecular mechanisms are still unknown. The aim of this chapter is to provide a short overview of the best-characterized molecular mechanisms of epigenetic inheritance and then continue and focus on yet to be explored, perspective mechanisms. The chapter concludes with an overview of the pote
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