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Titlebook: BetaSys; Systems Biology of R Bernhelm Booß-Bavnbek,Beate Klösgen,Erik Renström Book 2011 Springer Science+Business Media, LLC 2011 diabete

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发表于 2025-3-21 17:23:59 | 显示全部楼层 |阅读模式
期刊全称BetaSys
期刊简称Systems Biology of R
影响因子2023Bernhelm Booß-Bavnbek,Beate Klösgen,Erik Renström
视频video
发行地址This book uses the example of regulated exocytosis in pancreatic ß-cells, and it’s relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications In using a f
学科分类Systems Biology
图书封面Titlebook: BetaSys; Systems Biology of R Bernhelm Booß-Bavnbek,Beate Klösgen,Erik Renström Book 2011 Springer Science+Business Media, LLC 2011 diabete
影响因子.BetaSys. uses the example of regulated exocytosis in pancreatic β-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications..
Pindex Book 2011
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发表于 2025-3-21 23:28:29 | 显示全部楼层
Mitochondria and Metabolic Signals in β-Cellsexocytosis. In response to a glucose rise, nucleotides and metabolites are generated by mitochondria and participate, together with cytosolic calcium, in the stimulation of insulin release. This chapter describes the mitochondrion-dependent systems of regulated insulin secretion.
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β-Cell Ontogenesis and the Insulin Production Apparatusas demonstrated that most of these genes are expressed in the pancreatic β-cell and are involved in not only transcriptional functions but also the insulin secretory apparatus. This chapter provides a short overview of these subjects.
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Institutioneller Wandel durch Lernprozesseom human and animal studies show that amyloid develops before β-cell deficiency, and the occurrence of oligomers and amyloid intracellular induces β-cell death. Prevention of islet amyloid most likely will save β-cells and extend hormone secretion.
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Evaluation/Empfehlungen und Ausblick as well as recent advances in the understanding of the pathogenesis of type 2 diabetes. This disease represents one of major health problems associated in economically developing countries, but recently a much improved understanding of the genetic risk for the disease has opened up the prospect of personalized treatment.
发表于 2025-3-22 23:59:17 | 显示全部楼层
https://doi.org/10.1007/978-3-658-35097-0 viable transplanted islets. β-cells labelled in vivo with Mn. ions can be measured as signal hyperintensity on MR images, since Mn. ions enter β-cells through voltage-gated Ca. channels. Compartmental models that describe Mn. distribution in the pancreas may provide quantitative measurements of β-cell mass and function.
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