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Titlebook: Behavioral Pharmacology; The Current Status Bernard Weiss,Victor G. Laties Book 1975 Springer Science+Business Media New York 1975 pharmaco

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An experimental analysis of behavioral factors in drug dependence pointed the way toward such an objective analysis, it wasn’t until the late 1950’s that this promise began to be realized. The new scientific domain, behavioral pharmacology, grew principally out of an amalgamation of the concepts of an operational analysis of behavior propounded by Skinner (63, 64
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Experimental models for the modification of human drug self-administrationt the evaluation of manipulated variables. When a variety of restrictions on ethanol availability have been imposed, sensitive self-administration baselines have been established which have permitted the direct experimental assessment of some of the determinants of ethanol self-administration. Six m
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Neurochemical changes associated with schedule-controlled behaviorvertheless support the concept of dynamic changes within the extracellular environment of the CNS that may be part of a hormone-like communicating system with functional significance. Furthermore, the presence of peaks and/or troughs, in perfusates, of [.C]urea or similar substances should not be ta
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Catecholamines and drug—behavior interactionseby the subsequent drug effect. Experiments measuring the depletion of catecholamines following synthesis inhibition with αMT, or changes in the specific activity of norepinephrine after tritium labeling, have shown that operant behavior alters the metabolism of catecholamines. Preliminary evidence
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Assessing the impact of low level chemicals on development: behavioral and latent effectsocess may have only delayed effects. A morphological or biochemical lesion can be dormant and not manifest itself until later in life as a behavioral disorder, mental deficiency, or overt functional impairment. Longitudinal evaluation is required to detect long-term or delayed effects of a particula
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