| 期刊全称 | Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease | | 影响因子2023 | Hoa Huu Phuc Nguyen,M. Angela Cenci | | 视频video | | | 发行地址 | Gives an overview of the clinical aspects of Huntington’s Disease (HD) and Parkinson’s Disease (PD) and reviews the construct, face and predictive validity of animal models.Provides information on whi | | 学科分类 | Current Topics in Behavioral Neurosciences | | 图书封面 |  | | 影响因子 | Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders. | | Pindex | Book 2015 |
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发表于 2025-3-21 17:36:18
