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Titlebook: Behavioral Clinical Trials for Chronic Diseases; Scientific Foundatio Lynda H. Powell,Kenneth E. Freedland,Peter G. Kauf Book 2021 Springer

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The Choice of a Comparator,one-size-fits-all” comparator that controls for non-specific treatment factors. The recent emergence of frameworks for comparator choice aims to create explicit rules which place a priority on the primary purpose of the trial within its developmental context. This chapter reviews implicit and explic
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Protection of Random Assignment,eatment and undermines the ability to make causal inferences. This chapter focuses on why random assignment is so powerful and should be protected. It presents a history of attempts to answer the question of whether or not a treatment works, and the arrival at random assignment as the best way to ma
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Epilogue,ion and management of chronic diseases. It is a guide to the science, strategies, methods, and processes that produce the data needed to close the gap between discovery and uptake in clinical practice.
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