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Titlebook: Basophil and Mast Cell Degranulation and Recovery; Ann M. Dvorak Book 1991 Springer Science+Business Media New York 1991 Lipid.Organelle.c

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Rat Mast Cells,e long after the effect of histamine on vascular permeability and smooth muscle contraction were known. The histamine content, 5-hydroxytryptamine (5-HT) content, and mast cell numbers were shown to vary in parallel from various regions of the skin in rats (West, 1959). Histamine releasers given to
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,Biochemical Contents of Granules and Lipid Bodies—Two Distinctive Organelles Found in Basophils andunique to these cells. For example, all secretory cells capable of regulated secretion store their unique secretory products in membrane-bound secretory granules (Palade, 1975), and non-membranebound lipid bodies are present in a large variety of mammalian cells including adipocytes (Galli .., 1985)
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Ultrastructural Morphology of Basophils and Mast Cells,different to be assigned to one of these two lineages in most species (A. M. Dvorak, 1986b, 1988b; A. M. Dvorak .., 1983a). The general and specific ultrastructural criteria for doing so are listed in Table I. Since immature basophils, or basophilic myelocytes, are large mononuclear cells filled wit
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Recovery of Basophils and Mast Cells from Degranulation,hils or mast cells (A. M. Dvorak, 1988a,b, 1989a,b; Galli .., 1984, 1990). Rather, and like secretory cells in general, basophils and mast cells survive these release events. In AND, a completely degranulated cell has diminished numbers of entire granules, i.e., both the contents and the containers,
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Concluding Remarks,research directions have been identified. Basophils and mast cells, although closely related cells functionally, developmentally, and morphologically, are sufficiently distinctive by ultrastructural criteria that they can be reliably identified despite the morphologically complex phenotypes imposed
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Introduction,aneous basophil hypersensitivity (CBH) to distinguish them from classical delayed hypersensitivity (DH) skin reactions (H. F. Dvorak, 1974; H. F. Dvorak .., 1970). The study of basophil and mast cell biology has been a major part of our ultrastructural research efforts during the past 20 years.
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Recovery of Basophils and Mast Cells from Degranulation, whereas in PMD, a completely degranulated cell has released the contents of the granules and retained the containers. Recovery (after AND) of containers and contents or (after PMD) of contents, then, may be necessary if these viable cells are to renew their secretory functions.
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