Titlebook: Basics of Hematopoietic Stem Cell Transplant; Sanjeev Kumar Sharma Book 2023 The Editor(s) (if applicable) and The Author(s), under exclus

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Basics of Stem Cell Transplant of replacing the defective or damaged hematopoietic system of the recipient. Conditioning chemotherapy is given before SCT. The conditioning, also called as a preparatory step prior to stem cell infusion, is generally considered the most important step in the SCT procedure, and it includes myeloabl

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Hematopoiesisod in the bone marrow to produce and replenish the blood-forming cells. Studying steps of hematopoiesis help the transplant physicians understand the processes of blood cell development, diseases arising from the defects in their development, and how stem cell transplant replenishes the complete hem

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Role of Thymusnd an inner medulla. Hematopoietic stem cells reside in the bone marrow and continuously keep supplying progenitor stem cells to the thymus to maintain the export of naïve T cells. The thymus-dependent regeneration of T cells after stem cell transplantation (SCT) is similar to physiologic events tha

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Immunology of Stem Cell Transplantationl to generate all the cells of hematopoietic system but also transfer the cells involved in the immunity. These cells of immunity are transferred along with the graft as well as generated from donor stem cells after engraftment. Hematopoietic SCT is different from solid organ transplant in that cell

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Dendritic Cellsf the events occurring after allogeneic hematopoietic stem cell transplantation (SCT). They are implicated in the development of acute and chronic graft-vs-host disease (GVHD), graft-vs-leukemia (GVL) effect, and in immune reconstitution. DCs recover promptly following SCT, however, their recovery i

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T Cell Malignanciess more than 25% blasts. T cell lymphomas can be divided into those of precursor T cells (i.e., precursor T lymphoblastic lymphoma) and those developing from more mature T cells, termed peripheral T cell lymphomas (PTCL). T cell malignancies are aggressive malignancies with poor prognosis.