Titlebook: Basic Knowledge of Pharmacology; Roland Seifert Textbook 2019 Springer Nature Switzerland AG 2019 Pharmacology class reading.Medical and p

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Drug Allergye result of mast cell degranulation and can lead to anaphylactic shock and death within a very short period of time. I.v. epinephrine (EPI) injection by the physician or the i.m. EPI injection by the patient (auto-injector) constitute the most important therapeutic measures. Type II reactions are ch

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Dopaminergic Systemusion and cardiac function and to induce vasoconstriction. In PD, there is a loss of function of dopaminergic nigrostriatal neurons with consequent dominance of cholinergic neurons. This results in rigor, tremor, and akinesia. PD symptoms can be alleviated via stimulation of the dopaminergic system

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NO-cGMP Systemells is the most important function of cGMP. cGMP is degraded by PDE5. The NO donor GTN activates sGC and relaxes smooth muscle cells. This effect is used for the treatment of AP, hypertensive emergency, and visceral pain. The NO donor SNP is used for otherwise resistant hypertensive emergency. Long

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Pain Pharmacology on the specific cause of pain. Analgesics are divided into MOR agonists and non-MOR agonists. The COX inhibitors ibuprofen and diclofenac, also possessing anti-inflammatory effects, belong to the non-MOR agonists. Paracetamol and metamizole lack the anti-inflammatory component of COX inhibitors. Ac

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Immunopharmacologyt the transplant is raised, impairing organ function. It is the therapeutic goal to suppress symptoms of the immune process as far as possible without compromising the function of the immune system in host defense against infections and tumor cells too seriously. In many patients, these goals can be