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Titlebook: Basic Aspects of Receptor Biochemistry; Proceedings of the I Menek Goldstein,Kurt Jellinger,Peter Riederer Conference proceedings 1983 Spri

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Calmodulin, Ca2+-Antagonists and Ca2+-Transporters in Nerve and Muscle,t from the antiporter of heart mitochondria. These results are discussed in terms of Ca.-binding proteins being potential targets for pharmacological interventions designed to block specific aspects of the action of calcium.
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Regulation of Noradrenergic Receptor Systems in Brain that Are Coupled to Adenylate Cyclase,ological responsiveness of NE receptor systems, the number of receptors and the efficacy of their coupling to adenylate cyclase appear to represent control mechanisms for the intensity of signal transfer.
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The Search for Selective Dopaminergic Autoreceptor Agonists, and it is suggested that compounds such as (−)-3-PPP may find future clinical application as “second-generation” antipsychotic agents, lacking in the debilitating motor side effects produced by drugs in current therapeutic use.
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Evidence That the D-2 Dopamine Receptor in the Intermediate Lobe of the Rat Pituitary Gland Is Assonylate cyclase activity; apomorphine, a dopaminergic agonist, abolishes this effect of GTP. It is hypothesized that the D-2 dopamine receptor in the IL interacts with an inhibitory guanyl nucleotide component (N.); stimulation of the D-2 dopamine receptor alters the properties of N. so that N. can i
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,Evidence for the Existence of Receptor—Receptor Interactions in the Central Nervous System. Studies change the characteristics of the .H-N-propylnorapomorphine (.H-NPA) binding sites in striatal membranes of rats. Glutamate (10. M) increases the density and especially reduces the affinity of the .H-NPA binding sites, which label D. and D. types of DA receptors..Taken together the present findings
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Long-Term Adaptive Changes in Striatal Dopamine Function in Response to Chronic Neuroleptic Intake g on striatal cell bodies and on the terminals of cortico-striate glutamate terminals..In summary, neuroleptic drugs induce a series of adaptive changes on chronic administration consistent with the development of functional striatal dopamine receptor supersensitivity.
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https://doi.org/10.1007/978-3-642-45967-2oreover half of these labelled contacts were differentiated in synapses of the asymmetric type. When the animals were pretreated with haloperidol in order to block the dopaminergic binding sites, we found a decrease in the total number of the number of silver grains. A decrease in the number of clus
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