Titlebook: BRAF Targets in Melanoma; Biological Mechanism Ryan J. Sullivan Book 2015 Springer Science+Business Media New York 2015 BRAF-inhibitors.Nex

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Parallel and Serial Blockade Strategies in BRAF-Mutant Melanoma,atalytic activity and its downstream effectors in the RAS-RAF-MEK-ERK signaling pathway. Both selective BRAF and MEK inhibitors have demonstrated high clinical response rates in metastatic melanoma patients with activating . mutations. These successes have illustrated several keys to the successful

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