Titlebook: B Cells in Immunity and Tolerance; Ji-Yang Wang Book 2020 The Editor(s) (if applicable) and The Author(s), under exclusive license to Spri

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Aldo de Luca,Stefano Varricchioerminally differentiated from activated B cells and are specialized for secreting antibodies. Plasma cells are generated during extrafollicular or germinal center (GC) responses, but GC-derived plasma cells are thought to be the major precursors of long-lived plasma cells, which confer long-term pro

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Aldo de Luca,Stefano Varricchiodies have revealed that IgM also plays an important role in immune regulation and immunological tolerance. Mice lacking secretory IgM not only exhibit impaired production of antigen-specific IgG and are more susceptible to bacterial and viral infections, but also produce autoantibodies and are prone

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