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Titlebook: B Cell Receptor Signaling; Tomohiro Kurosaki,Jürgen Wienands Book 2016 Springer International Publishing Switzerland 2016 B cell developme

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发表于 2025-3-21 17:03:54 | 显示全部楼层 |阅读模式
期刊全称B Cell Receptor Signaling
影响因子2023Tomohiro Kurosaki,Jürgen Wienands
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发行地址Discusses current models of how the B cell antigen receptor becomes activated.Focusses on the elucidation of intracellular B cell receptor signaling pathways.Describes modulation of B cell activation
学科分类Current Topics in Microbiology and Immunology
图书封面Titlebook: B Cell Receptor Signaling;  Tomohiro Kurosaki,Jürgen Wienands Book 2016 Springer International Publishing Switzerland 2016 B cell developme
影响因子.Thisvolume details our current understanding of the architecture and signalingcapabilities of the B cell antigen receptor (BCR) in health and disease. Thefirst chapters review new insights into the assembly of BCR components andtheir organization on the cell surface. Subsequent contributions focus on themolecular interactions that connect the BCR with major intracellular signalingpathways such as Ca.2+. mobilization, membrane phospholipidmetabolism, nuclear translocation of NF-kB orthe activation of Bruton’s Tyrosine Kinase and MAP kinases. These elementsorchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamicsfor antigen internalization. Furthermore, a key mechanism of how B cellsremember their cognate antigen is discussed in detail. Altogether, the discoveriespresented provide a better understanding of B cell biology and help to explainsome B cell-mediated pathogenicities, like autoimmune phenomena or theformation of B cell tumors, whilealso paving the way for eventually combating thesediseases..
Pindex Book 2016
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Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis,lper T cells. B cell antigen internalization is initiated by antigen capture, either from solution or from immune synapses formed on the surface of antigen-presenting cells, and proceeds via clathrin-dependent endocytosis and intracellular routing to late endosomes. Although the components of this p
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BTK Signaling in B Cell Differentiation and Autoimmunity,(XLA) in 1993, our knowledge on the physiological function of BTK has expanded impressively. In this review, we focus on the role of BTK during B cell differentiation in vivo, both in the regulation of expansion and in the developmental progression of pre-B cells in the bone marrow and as a crucial
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The Memory Function of the B Cell Antigen Receptor, of memory B cells (MBCs). The former population constantly produces serum immunoglobulins with sufficient specificity and affinity to thwart infections with recurrent pathogens. By contrast, memory B cell populations retain their antigen receptors on the cell surface and hence need pathogen-induced
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PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL),igens. The B cell receptor (BCR) is a transmembrane antibody, which facilitates the clonal selection of B cells producing secreted antibodies of the same specificity. The diverse antibody repertoire is generated by V(D)J recombination of heavy and light chain genes, whereas affinity maturation is me
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Role of Calcium Signaling in B Cell Activation and Biology, diverse Ca. signals finely controlled by multiple factors participate in the regulation of gene expression, B cell development, and effector functions. B cell receptor (BCR)-initiated Ca. mobilization is sourced from two pathways: one is the release of Ca. from the intracellular stores, endoplasmic
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,Roles of the NF-κB Pathway in B-Lymphocyte Biology,ction in the regulation of immunoglobulin κ light-chain gene remains unclear, NF-κB plays critical roles in development, survival, and activation of B lymphocytes. In B cells, many receptors, including B-cell antigen receptor (BCR), activate NF-κB pathway, and the molecular mechanism of receptor-med
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